THIOREDOXIN-INTERACTING PROTEIN-ACTIVATED INTRACELLULAR POTASSIUM DEPRIVATION MEDIATES THE ANTI-TUMOUR EFFECT OF A NOVEL HISTONE ACETYLATION INHIBITOR HL23, A FANGCHINOLINE DERIVATIVE, IN HUMAN HEPATOCELLULAR CARCINOMA

Introduction: Hyperactivated histone deacetylases (HDACs) act as epigenetic repressors on gene transcription and are frequently observed in human hepatocellular carcinoma (HCC).Although multiple pharmacological HDAC inhibitors (HDACis) have been developed, none is available in human HCC.Objectives: To investigate the pharmacological effects of a fa

Recently, a population-based intelligent optimization algorithm research has been combined with multiple algorithms or algorithm components in order to improve Tops - Bralettes the performance and robustness of an optimization algorithm.This paper introduces the idea into real world application.Different from traditional algorithm research, this pa

Due to the tremendous advancement in interactive multimedia systems and technologies, security has become a major aspect.Advanced technology can be utilized for THERMAL PROTECTANT SPRAY hacking autonomous systems like Unmanned Aerial vehicles (UAVs) in different ways such as spoofing and jamming.It can be spoofed by the injection of fake signals in

Introduction: The use of anesthesia information management systems (AIMS) is on the increase.This is particularly true for academic anesthesia departments.The main reasons for slow adoption of these systems in the past are financial barriers associated with implementation of these systems and their not so traditionally obvious potential to improve